With a growing number of global challenges related to the environment, water, public health, and energy, there is an imminent need to teach chemistry in the context of its interconnectedness with other systems. Project- and problem-based learning are student-centered learning approaches which offer educators the opportunity to engage learners in solving complex real-world problems. By choosing a globally relevant project/problem and requiring students to utilize scientific methods to solve the problem, both problem-based learning and project-based learning are excellent strategies for educators to teach chemistry using a systems approach. This review summarizes key research studies which utilize project- and problem-based learning in the context of enabling learners to confront global problems and the wide applicability of these approaches to systems thinking.