This research aims to investigate the impact of Common Knowledge Construction Model (CKCM) based science education teaching on the entrepreneurship skills of the eight grade students. The participants of this research are 50 students; 25 in control group (10 girls and 15 boys) and 25 in experimental group (9 girls and 16 boys). Quasi-experimental method was employed in the study. Entrepreneurship Scale and Semi-structured entrepreneurship interview forms were used. While the data of the Entrepreneurship Scale were analysed using dependent and independent t-test, the semistructured Interview were analysed by content and descriptive analysis. The findings showed that current teaching process applied in CKCM-based science teaching and control group (5Es learning model) was effective on entrepreneurial skills of secondary school students. When the experimental and control groups were compared, it was found out that in the experimental group, science teaching based on CKCM was more effective on the entrepreneurial skills of students as opposed to the 5Es learning model-based science teaching used with the control group students. The effect of CKCM on entrepreneurship skills could be more clearly identified if more research is taken with different levels of teaching.