Purpose: This study examines the effects of reverberation and noise fluctuation on the response time (RT) to the auditory stimuli in a speech reception task. Method: The speech reception task was presented to 76 young adults with normal hearing in 3 simulated listening conditions (1 anechoic, 2 reverberant). Speechlike stationary and fluctuating noise were used as maskers, in a wide range of signal-to-noise ratios. The speech-in-noise tests were presented in a closed-set format; data on speech intelligibility and RT (time elapsed from the offset of the auditory stimulus to the response selection) were collected. A slowing down in RTs was interpreted as an increase in listening effort. Results: RTs slowed down in the more challenging signal-to-noise ratios, with increasing reverberation and for stationary compared to fluctuating noise, consistently with a fluctuating masking release scheme. When speech intelligibility was fixed, it was found that the estimated RTs were similar or faster for stationary compared to fluctuating noise, depending on the amount of reverberation. Conclusions: The current findings add to the literature on listening effort for listeners with normal hearing by indicating that the addition of reverberation to fluctuating noise increases RT in a speech reception task. The results support the importance of integrating noise and reverberation to provide accurate predictors of real-world performance in clinical settings.