This study was an investigation into drug use and sources of drug information among secondary school students in Imo State, Nigeria. A sample of 1400 students, aged 16-17 years was studied. Percentages were used to describe the students' drug use and sources of drug information. Chi square was used to verify the four hypotheses postulated for the study. Results showed that the main drugs the students who took part in the study used included analgesics, stimulants, anti-malaria, alcohol, worm expellants, nasal decongestants, sleeping pills, laxatives, and anti-biotics and their main sources of drug information included print media, television, radio, and friends and peers. Chi-square tests indicated that the differences in the use of drugs between boys and girls were significant in most cases. It is recommended that drug education be made an integral part of secondary school curriculum.