Hispanic-serving institutions (HSIs), those institutions with 25% or more enrolled Latinx students, are an increasingly common part of the U.S. higher-education landscape. Their growth coincides with the increasing Latinx population--from 55 million in 2015 to an estimated 119 million by the end of 2060. Latinx students hail from a variety of countries, such as Mexico, Puerto Rico, Cuba, Salvador, Dominican Republic, Guatemala, Colombia, Honduras, Ecuador, and Peru. The ability of HSIs to support the wide range of cultural, linguistic, and national heritages that characterize the Latinx, and non-Latinx, student population while addressing anti-Latinx sentiments and policies provides an important space for understanding how to create inclusive campuses within and beyond the HSI context. The challenges that face HSIs, and the potential they have to create new understandings of diversity, inclusion, and power-sharing, merits their place as a "wicked problem." Although HSIs do not have the same political impetus for their creation that historically black colleges and universities (HCBUs) or tribal colleges, they are often characterized by a commitment to promote Latinx student success as an institutional goal. Research in this area, in fact, suggests that HSIs can play an important, positive role in Latinx student success. Despite the benefits HSIs offer, there are challenges--both internal and external--to their success. The first challenge is the demographic mismatch of those who work in, and attend, HSIs. Another issue is the increasingly hostile cultural and political landscape for Latinx people, particularly those who are first-generation immigrants or undocumented. HSIs, therefore, have a great deal of work ahead of them as they seek to fulfill their institutional missions. The authors describe how the forum's contributors offer insights into how to navigate these challenges.