The purpose of this study was to develop a predictive population model with respect to quality of life, school violence, and family dynamics in adolescent students from Medellín, Colombia. Cross-sectional, explanatory study was realized with 3460 adolescents using probability sampling for selection. Structural equation modeling was performed. The results of this study showed that the quality of life of adolescents is determined based on physical health, psychology, leisure time, relationship with parents, peer support, and perception of academic well-being. School violence negatively affects quality of life; bullying is the factor with the least predictive capacity, and relationship with teachers is the most predictive factor. The improvement of family dynamics is associated with an improvement in quality of life. The results show lines of action to guide the design of intersectoral and interdisciplinary policies aimed at family dynamics and the school environment as primary support networks for improving adolescents' quality of life.