We systematically reviewed more than 25 years of applied research examining the system of least prompts response prompting procedure with individuals with disabilities. We identified 123 peer-reviewed studies including 413 participants receiving instruction with the system of least prompts. A total of 252 experimental designs were evaluated, with 51 designs indicating a functional relation and the presence of 154 demonstrations of effect across 91 individuals. Our data indicate that the system of least prompts is an evidenced-based practice for teaching chained responses related to community, self-care, and vocational skills to individuals with moderate intellectual disability who are 13 years of age or older. In addition, we present and discuss a method for analyzing and aggregating data from single-case studies to account for noneffects and publication bias when identifying if an intervention meets standards as an evidence-based practice.