The purpose of the study was to determine the influence of an instructional strategy for the use of DOKEOS, Course Management System (CMS) on the attitudes of professors toward distance education. The study was carried out in the Faculty of Accounting and Administration of a Mexican Public University. The research design was non-experimental with a group of twenty-five professors who were selected through purposive sampling. A questionnaire, which was an attitude scale toward the use of an administration system of online courses, was administered to participants before and after the implementation of an instructional strategy on the use of DOKEOS. Afterwards, usage statistics was examined between weeks three and six. Data analysis included calculation frequency, median, mode and standard deviation. The significant differences between the median of the pre-tests and post-tests were analysed, and then the t-test was administered. Results showed that the instructional strategy contributed to a more positive attitude of professors toward distance education.