Computer Assisted Instruction (CAI) is one form of advances in information technology and computers that are proliferating today that can access anywhere and can be utilised as innovative learning resources. This research aims to develop Android-based Computer Assisted Instruction and evaluate its effectiveness. The Android-based CAI media were designed to improve students' ability both in Statistics and self-regulated learning. The development stages of this media referred to Borg & Gall R & D procedures that consist of 10 stages. Waterfall method was used to develop the Android-based CAI programming. Population in this research was the student of the first year in the mathematics education program. The sample for a small trial class and operational field testing was carried out using purposive sampling. The research used two non-test instruments: validation sheet and questionnaire to collect the data while descriptive analysis was used to analyse the data. At the end of the research, an application called Statistical Data Analysis (SDA) was produced, and it can be downloaded free on Google Play. Based on the results, it can be concluded that Android-based CAI is valid to be used as a learning resource, flexible, and supporting students' self-regulated learning.