As students move through the grades, content area learning becomes increasingly significant for reading, writing, and speaking tasks. One research-evidenced approach to actively engaging adolescent learners in acquiring, remembering, and using academic vocabulary in reading, writing and speaking tasks across disciplines is multisensory structured metacognitive language (MSML) instruction. In this article, a variety of such MSML strategies are shared with specific examples relating to content disciplines. They help to strengthen teachers' confidence in implementing research-evidenced prefix-root-suffix vocabulary learning strategies with their adolescent students. Selective examples of how to assess learner performance are provided in such a way that they can be adapted for different academic contexts.