College students can be advocates for people with disabilities. Collaboration on community projects in a school of computer science and information systems can be desirable for people with disabilities and students. The authors analyze the collaborative impacts from courses in Web Design for Non-Profit Organizations with moderately impaired but nimble people with cognitive disabilities. The authors find course features of e-Portfolios facilitating the engagement and the advocacy of the students for mentored people with disabilities. The findings can help instructors in information systems in cultivating e-Portfolios on course projects of students with those with disabilities.