The way that individuals perceive their well-being may vary depending on their self-efficacy especially towards a difficult life situation, such as the physical disability. The aim of this study is to examine the relationships among problem solving self-efficacy, resilience self-efficacy and subjective well-being and the differentiation among these factors between people with and without physical disabilities. A self-report questionnaire was administered to 150 individuals with physical disabilities and 150 individuals without disabilities in Greece. Results showed positive correlations among problem solving self-efficacy, resilience self-efficacy and subjective well-being, while statistically significant differences were found in the level of the above factors between participants with and without disability. Furthermore, the need for an escort and the satisfaction with transportation autonomy could predict much variance in self-efficacy and subjective well-being for individuals with physical disabilities. The implications of findings for the psychosocial adjustment of people with physical disabilities are discussed.