The article presents a new adaptation programme entitled 'With a smile to school' for pupils of the first year at primary schools. The adaptation programme comprises several methods and measures which are focused on the regulation of pupils' adaptation process. The efficiency and effectiveness of the adaptation programme were verified through an experiment at selected primary schools in Slovakia in the school year 2016/2017. Based on the experiment results, a proposal for implementation of the adaptation programme to school practice was drawn up. The experiment results were evaluated by means of selected statistical methods.