This study identifies new areas for risk-reduction strategies and research with regular cannabis users. Participants at a cannabis advocacy event in the Midwestern USA completed a survey including items from the Behavioral Risk Factor Surveillance System. Most participants (70%) reported using cannabis to treat a medical condition, though a smaller portion (28%) had a medical marijuana card. Participants reported several health risks associated with cannabis use, including driving a vehicle while high on cannabis, using cannabis laced with some other drug and having more intense experiences than they intended. Nearly one-quarter of participants indicated they did not have any health care coverage and; consequently, not being able to see a doctor when they needed to because of the cost. The findings indicate a variety of health issues in cannabis users that warrant attention from health educators and researchers. Additional research is needed to evaluate the effectiveness of health-promoting interventions in this population.