Although Attention Deficit Hyperactivity Disorder (ADHD) affects approximately 5% of children, the disorder is more frequently seen in males than in females, with a male-to-female ratio of approximately 2:1 in children (APA 2013). This discrepancy in prevalence is suggested to lie in the differences in ADHD symptomatology between girls and boys. Girls commonly present with more inattentive features and less hyperactive/impulsive features when compared to boys, resulting in more diagnoses of the inattentive presentation for girls than for boys (Hinshaw, Owens, Sami, & Fargeon, 2006; Skogli et al., 2013). Therefore, accurate understanding and recognition of inattentive symptoms becomes vital for properly diagnosing and treating females with ADHD. According to Rucklidge (2010), the neglect of inattentive symptomatology consistently leaves many girls unrecognized, undiagnosed, and untreated. Because impairment may not be suspected by teachers or parents, girls have less opportunity to self-report symptoms and attain help. This paper explores the linkage between gender-based differences in neuroanatomy and symptomatology of children with ADHD. Implications and strategies for practitioners are also discussed to promote the appropriate identification and treatment of girls with ADHD.