This quantitative inquiry aimed to investigate plausible generational differences among Hispanic learners in the context of e-learning. The investigation examined students' technology ability, learning activity preference, attitude towards technology use, and instructional strategy orientation at a Hispanic-serving institution (HSI) of higher education along the southern border with Mexico. The researchers studied whether age is the dominant factor affecting learners' technology ability, learning activity preference, attitude towards technology use, and instructional strategy orientation after controlling for students' preferred course delivery mode and academic status. Limitations and recommendations were addressed.