This article integrates two frameworks, Quality Matters (QM) and tenants of Universal Design for Learning (UDL), in the development and implementation of online learning courses. Both of these frameworks are described. This report highlights guidelines and presents an example for creating quality online courses with a combined emphasis on course content and course delivery system. These guidelines underscore the need for advance planning of content and delivery methods. Quality Matters (QM) provides a standards-based, collaborative peer review process to assure the quality of online courses (Varonis, 2014). Universal Design for Learning is a set of principles for curriculum development that give all individuals equal opportunities to learn. The goal of this practical summary is to provide guidance about elements that are recommended to faculty as they plan for highly effective, goal oriented and interactive online instruction and student learning.