In the past decade, the importance of teamwork training in higher education and employers' enthusiasm for recruiting team players have been widely discussed in the literature. Yet, the process through which effective teamwork training is developed in a higher education setting has not yet been properly discussed. The present study aims to map the precedence relationships among the key determinants of teamwork training effectiveness and explain the process through which an effective teamwork training program can be developed. The study first conducted an extensive review of the literature to highlight the key determinants of effective teamwork training. Next, the study benefitted from an interpretive structural modeling technique and captured the opinions of a group of teamwork training experts to further map the interrelationships among the potential determinants that were identified. By listing the key determinants of effective teamwork training, mapping their interrelationships, and identifying their driving and dependence power, the present study is expected to help practitioners and academicians through providing a detailed understanding of the process through which an effective teamwork training program can be developed in a higher education context.