The transition to university is a stressful period for young adults; however, there has been limited research examining the predictive role of dispositional mindfulness in supporting first-year students' adjustment to university. The current study sought to examine the relative contribution of gender, self-efficacy, perceived social support from friends and family, and dispositional mindfulness to domains of university adjustment (academic, social, personal or emotional, and institutional attachment). The sample consisted of 101 first-year university students (73% female; M = 18.20 years, SD = 0.79) and all data were collected using an online survey. Findings revealed dispositional mindfulness significantly predicted university adjustment even when controlling for self-efficacy and perceived social support. The present study is the first to provide empirical support for the protective role of dispositional mindfulness in university adjustment.