Many current science, technology, engineering, and mathematics (STEM) initiatives and projects aim to scale change and encourage more departments, units, and institutions to engage in the evidence-based teaching practices that enhance student learning and outcomes. The authors of this article examined change strategies and networking efforts in a recent study of the Association of American Universities (AAU) undergraduate STEM education initiative (AAU STEM Initiative). What emerged in this study is the particular importance of a "network of networks." Many interviewees in the study noted that there are far fewer networks to support teaching, particularly among prestigious or elite institutions. This suggests that multiple networks are needed that work across the system of higher education to create a broad web of support and value. It is this type of work that AAU engaged in as part of the AAU STEM Initiative--creating a "network of networks." In this article, the authors review the work by AAU to create networks in support of scaled change, the functions that these networks serve, and the promising practices and lessons that others may wish to adopt that will be helpful to further change efforts.