Aiming at many problems of school multimedia classroom management, a remote control system for multimedia classroom based on cloud computing is developed. The system includes cloud computing management platform, network switch, single-chip microcomputer and equipment in the multimedia classrooms. It uses VMware desktop virtualization technology to deploy virtual machine templates of different courses in each classroom through the campus network. It controls all multimedia equipment in each classroom by single-chip microcomputer remote control. In terms of software and hardware, key problems such as multithreading, socket communication and remote control are solved and a single-chip microcomputer is developed to control the classroom equipment through the serial ports automatically. Compared with the traditional system, the system based on cloud computing has the advantages of rapid deployment and unified management. It improves the teaching effects of multimedia course and it reduces the construction and maintenance of multimedia classrooms.