This essay discusses the current state of and potential future directions for information systems education structured around several key themes that have emerged as central in several large-scale IS education initiatives over the past 15 years. The core idea that connects all of these themes is the centrality of IS as a transformative enabler for virtually all goal-directed human activities. The essay emphasizes the role of IS as the initial integrative discipline that for decades has prepared its students to identify opportunities to fundamentally change multiple target domains with computational capabilities. Furthermore, the discussion recognizes the distinctive focus of IS on bringing multiple technologies together into systems that serve organizational and societal goals and underscores the responsibility to carefully consider implications and potential consequences of technology-based solutions. The essay also acknowledges the essential roles of formal quality assurance mechanisms (such as accreditation) and education-focused research as essential resources for the future of the discipline.