With over 1,400 known disease-causing organisms in humans alone, and hundreds of named infections, the realm of Medical Microbiology is both fascinating and intimidating. The wealth of information covered in this subject area often demands much memorization that can be difficult to handle. By integrating key concepts and terminology of this subject into a disease-based game concept, student interest and engagement in class as well as retention of information and performance on exams can be greatly improved, however. Here, I will introduce the elements of this game-based activity and several suggestions of how it can be integrated into the classroom to foster active learning as well as greater interaction and communication among students.