Qualitative comparative analysis (QCA) is gaining ground in evaluation circles, but the number of applications is still limited. In this article, we consider the challenges that can emerge during a QCA evaluation by drawing on our experience of conducting one in the field of development cooperation. For each stage of the evaluation process, we systematically discuss the challenges we encountered and suggest solutions on how these can be addressed. We believe that sharing this kind of lessons learned can help evaluators become more familiar with QCA, shedding light on what it is to be expected when considering the application of QCA for an evaluation, at the same time reducing unfounded fears and promoting awareness of traps and requirements. The article can be insightful and potentially inspirational for both commissioners and evaluators.