Individuals with skills specific to innovation and entrepreneurial strategy are in high demand within the contemporary workforce. This demand transcends most, if not all, professions and career paths. Yet, entrepreneurial leadership education continues to be viewed mostly as a business-oriented domain. We expand the otherwise narrow scope of entrepreneurial leadership education through an examination of the effects of an interdisciplinary, project-based entrepreneurial leadership course on student proclivities to leading change. We used a retrospective pre- and post-measure pre-experimental design to conduct the study. Our findings indicate an increase across the sample (n = 62) in entrepreneurial leadership proclivity following course completion. The insights we generate reveal opportunities for strengthening collegiate entrepreneurial leadership curriculum and instruction and enhancing the capacities of students to become effective leaders of change (i.e., change agents).