The rise of populist nationalism in many parts of the world poses urgent challenges for higher education institutions. Normally zones of liberal values and reasoned argument as well as sources of expert information, constructive criticism and useful advice for societies, universities face increasing uncertainty as a result of political and popular attack in a wide range of countries. Doing nothing is probably not an option. The challenge facing higher education broadly is to understand and to respond effectively to a geopolitical and social reality that is qualitatively new and threatening. Effective response will require a degree of self-examination, a re-articulation of purpose and a reconfiguration of action across multiple domains of university life.