Background: Raising a child with autism spectrum conditions (ASC) presents many challenges and learning experiences for parents and other family members. There has been limited research to date on Irish parents' experience of raising a child with ASC. The aim of this study was to describe the experience of a sample of Irish parents who have a child on the autistic spectrum. Method: A series of 1:1 semi-structured interviews were conducted with parents in the Republic of Ireland. In total, 10 interviews were conducted. Thematic analysis was undertaken to identify themes. Results: Five main themes were identified: (a) blame and stigma; (b) isolation; (c) being vigilant; (d) advocacy; and (e) coping with autism. Conclusions: The findings of the study have implications for professionals who work with Irish families affected by autism. Although Ireland's movement towards social inclusion lags behind other countries, a number of the experiences faced by Irish parents are similar to that reported in other countries, suggesting a universality of ASC parenting experiences. The implications of this are discussed.