Background: Emotion regulation difficulties have been associated with depression and anxiety in typically developing individuals. However, until recently, the impact of emotion regulation difficulties for adolescents and young adults with autism spectrum disorder (ASD) has received little attention. We investigated emotion regulation difficulties from the perspective of those who would experience the sequelae. This included parents, teachers, and psychologists. Method: Seven focus groups with parents, teachers, and psychologists, and 7 interviews with adolescents and young adults with ASD were conducted. Results: Across the groups, participants discussed their triggers of distressing emotions, difficulties with emotional awareness, emotion regulation strategies, and the consequences of their distressing emotions. Both depression and anxiety were perceived as the most experienced distressing issues with the greatest consequences. Conclusions: The implications of the themes revealed in the interviews and focus groups are discussed in light in previous literature and may help to inform future interventions.