The past two decades witnessed continuous uptake of ICT in education, and the importance of teachers' beliefs for adopting ICT in education was revealed in the context of educational change. In recent years, the Mongolian educational system has placed more emphasis on student-centered education and the use of ICT in teaching and learning. Teacher training has become a local responsibility under the Education Master Plan (Government of Mongolia, 2006), New Education Standard and Core Curriculum which focus on the introduction of ICT into education and the implementation of student-centered education (Asian Development Bank, 2008; Ministry of Culture Education and Science, 2014). Despite the growing interest in using ICT for student-centered education, a limited number of studies exist in Mongolia to understand primary school teachers' perception on use of ICT for student-centered education. This study aims to understand the factors affecting teachers' perceptions on use of ICT for student-centered education. Based on Fullan's educational change theory, the analysis through multiple linear regression and focus group discussion was conducted on 838 primary school teachers in Mongolia which found that teachers' professional competency and perceived benefits on use of ICT are significant factors affecting teachers' perceptions on use of ICT tool for student-centered education. Furthermore, teachers' professional competency, perceived benefits on use of ICT and teacher cooperation are affecting teachers' perceptions on use of digital contents for student-centered education.