This study investigated the influence of physical and virtual learning spaces on interactive learning in a college and university setting. Qualitative analysis of an undergraduate liberal arts program that employs the use of roundtable classrooms was conducted. Interview and focus group data from students and faculty, along with classroom observations, resulted in the finding that the roundtable classroom encouraged interactive learning, face-to-face accountability, and verbal immediacy, along with a "cohort effect" and "fidget factor." Virtual learning spaces influenced interactive learning, and their effectiveness was heavily moderated by instructors and by the frequency and use of educational technology. Recommendations and suggestions for future research are provided.