The current study investigated the development of global and domain (academic, physical, same-sex peer relationship, opposite-sex peer relationship) self-esteem from age 10 to 16 in a sample of Mexican-origin adolescents. Participants' (N = 674) responses on the Self-Description Questionnaire (SDQ; Marsh, 2005) II-S showed moderate rank-order stability across four time points. In terms of mean-level change, global self-esteem and most forms of domain self-esteem decreased across adolescence; the one exception is that opposite-sex peer relationship self-esteem increased. As expected, there were individual differences in rates of change for all SDQ subscales. Most domain self-esteem subscales were concurrently related to global self-esteem (r's ranged from 0.18 to 0.87), but they did not predict changes in global self-esteem over time. Academic self-esteem had the strongest concurrent associations with global self-esteem. In general, there were no consistent gender differences in rank-order stability, mean levels, or change over time of global and domain self-esteem. These findings provide insight into the development of self-esteem in a rapidly-growing segment of the population of the United States.