The purpose of this article is to help leaders do their jobs more effectively by examining the components of brain-wise leadership. The article is divided into five parts: Part I is a general overview, defining brain-wise leadership, its traits, attributes and some of the styles of effective leadership. Part II begins with the strategies for effective and ethical decision-making and goes on to explain additional leadership and feedback skills that research finds effective. Part III helps the readers identify their leadership style; Part IV deals with issues that all leaders need to know about how the brain learns and functions. Part V deals with strategies for unleashing your personal energy and managing one's self in a stressful world. The payoff for investigating these processes and learning these strategies is to boost your performance and maximize your productivity and effectiveness as a leader.