This paper focuses on the development and evaluation of a Technology Enhanced Interaction Framework and Method that can help with designing accessible mobile learning interactions involving disabled people. This new framework and method were developed to help design technological support for communication and interactions between people, technology, and objects particularly when disabled people are involved. A review of existing interaction frameworks showed that none of them helped technology designers to consider all of the possible interactions that occur at the same time and in the same place (i.e. face to face situations). Since almost all learners and teachers now have access to mobile technologies the new framework and method provide great potential for learning through interactions in these face to face situations. The components of the framework are described and explained, and examples of interactions are provided. The Technology Enhanced Interaction Framework has been developed and validated using technology designers and accessibility experts. To help designers apply the framework, the method has been developed and validated using technology designers and accessibility experts, and was successfully evaluated with technology designers.