The present study aimed at examining the interpersonal aspects of depression among female college students. A sample of 60 undergraduate female college students (50 pairs: 25 depressed and 25 non-depressed subjects along with their best friends) was drawn from Government Degree College for Women, Multan. Beck Depression Inventory (Beck et al., 1961) was administered to both the depressed and non-depressed subjects along with their best friends (i) to fill it out for themselves, (ii) to fill it out for as would their friends (iii) and to fill out for, as would the average person. Statistical analysis showed that the best friends of depressed subjects were significantly more depressed than the best friends of non-depressed subjects. Results also suggested that depressed subjects perceived their best friends and the average persons to be more depressed as compared to the non-depressed subjects. No significant differences were found between actual and perceived scores of best friends of both the depressed and non-depressed subjects. Also, no significant differences were found between best friend's perception and actual scores of depressed and non-depressed subjects.