The disease burden of the Human Papillomavirus (HPV) among females and its associated sequelae have been widely studied by social and behavioral science researchers and medical professionals. Approved for administration to males as young as nine years old, the vaccination of males continues to spark much debate when older age groups are brought into the conversation (i.e. college students). Controversy stems from a review of cost-effectiveness models, social equity, cultural norms, ethics, and the contribution of HPV to the overall healthcare burden. College student health centers must determine if they are going to offer the HPV vaccine to any student and establish guidelines for offering the vaccine to females and/or males. This paper will discuss benefits and barriers to HPV vaccination of college males and demonstrate that a need for prevention programs is imperative so that both genders will seek out the vaccination.