A quantitative-qualitative historical content analysis of selected Seinfeld television comedy episodes was conducted for this study. Episodes were analyzed for the presence of health-related messages pertaining to the U.S. Centers for Disease Control and Prevention's health priority areas, which include the most harmful risk behaviors affecting today's youth. A random selection of 88 of 176 Seinfeld episodes aired from July 5, 1989 until its finale on May 14, 1998, resulted in 787 health-related messages for the study. Over the course of nine seasons, more health-related messages were found in later years.