This study investigated the effects and solutions of work and family conflict among female bankers in Accra Metropolis. Using triangulatory mixed method design, a structured questionnaire was randomly administered to 300 female bankers and 15 female Bankers who were interviewed were also sampled by using convenient sampling technique. The researchers employed both qualitative and quantitative methods of analysing data. Mean and standard deviation were used for quantitative data while the interview data was thematically analyzed to explain issues as they emerged in the study. The data outlined several effects of work and family conflict among female Bankers and these included stressors, ill-health, premature retirement, psychological burnout and procrastination. The study also pointed out the solutions to the effects of work and family conflict by female bankers. The solutions included the need for institutions to open preschool closed to workplaces for interested nursing mothers to send their wards, family support system, regular medical checkup and antenatal leave/causal leave. It therefore, recommended that the banking institutions should employ more staff, implement shift system to help reduce the workload and long hours of sitting by female bankers; and regular medical checks and exercise to help improve the ill-health experienced by female bankers. Furthermore, the banks should consider more technological ways of banking to help limit the number of customers who come to the banks each day.