The purpose of this study was to investigate into how female teachers in Asamankese Circuit II in West Akim Municipality of Ghana Education Service manage stress and teacher burnout, and explore the causes, effects, and ways of improving work-related stress for better standard of education. The study was conducted with qualitative research approaches executed through questionnaires. Twenty-five female teachers were selected from eighteen Primary and Junior High Schools through purposive sampling technique for the study. The study employed descriptive cross-sectional design particularly cross sectional survey design.The data collected were subjected to statistical analyses, frequencies and percentages, together with mean and standard deviation. The study revealed that the stress level of the female teachers was high. Work over-load and interpersonal relationship were the main causes of stress of the female teachers. Majority of the female teachers strongly agreed that stress made them perform below standard. Based on the findings of the study a number of recommendations were made. It was recommended that the government of Ghana should organize more training programmes on effective management of stressors by making use of different stress management strategies and providing effective guidance and counselling services. The government of Ghana should train more counselors to serve at the Basic schools.