This descriptive survey was carried out in order to determine the personal health risks behaviour profile among university students in the south east of Nigeria. A random sample of 900 students completed the questionnaire designed for the study. Out of this number 821, representing about 91.2% return rate, were used for data analysis. Means and standards deviations were used to describe the personal health risks behaviour profile of the students. T-test was used to test the entire hypotheses. Results showed that the respondents had no identifiable mental health-related, nutrition-related, physical activity-related, substance abuse-related and personal health care-related risks. T-test showed that no significant differences existed in most of the personal health risks behaviour profile between male and female respondents. Where significant differences existed, they inclined towards favouring the females. The study supports the need for compulsory health education curriculum activities to help educate the students in making healthy behaviour choices and leading a healthier lifestyle in order to improve or at worst maintain the status quo in their personal health risks behaviour profile.