The development of computer-assisted language learning (CALL) has created the opportunity for exploring the effects of the multimedia application on foreign language vocabulary acquisition in recent years. This study provides an overview the computer-assisted language learning (CALL) and detailed a developing result of CALL--multimedia. With the application of constructivism theory, the research explores the use of multimedia software to vocabulary acquisition. It presents a case study that uses survey method to explore the interest level of Chinese college students with the multimedia software they worked with and their attitudes towards multimedia application. Another purpose of the thesis is to examine the effectiveness of multimedia application among Chinese EFL learners.