The current study focused on an important issue pertaining to online social communication by investigating perceptional differences between eastern and western adolescents. A total of 309 participants were recruited from three countries: China, Singapore, and the United States. Significant differences were found between eastern and western adolescents in terms of their perceptions in online social networking and communication. The study has generated important findings that help understand the dynamics of online social communication for adolescents, especially for online social communication that involves global communities.