The activities that students participate in are important to college life and outcomes. With regard to the problem outcome of heavy drinking, some activities pose risks (e.g., fraternity/sorority life) and others are protective (e.g., religious groups), yet students often participate in multiple activities. We estimated the odds of frequent heavy drinking as a function of all 2-, 3-, and 4-activity combinations (out of 10 total activities) in 2 separate college cohorts of 1,005 and 592 students. Findings showed that activities indeed combine to form informative high- and low-risk groups for intervention and advising, adding additional insight into the theory of college involvement.