The pressures of the information and digital culture exhibit innovation, but also a hegemonic power, and act in reciprocity with the global economy. Theoretical concepts and practical actions need to be revisited, to build equity in virtual communication. A sociological-cultural focus of communication mediated by technology, cannot occur without holistic and trans-disciplinary attention, and its contrast in practice. This will result in wider interpretations with regard to the socio-historical, political and cultural explanations related to face-to-face and virtual socialization/education programs. The cultural studies and critical theory contribute to situate and deepen the study of these sociological-cultural-technological variables, within digital trans-media dynamic reality. They show how technology drives contradictory far-reaching changes in the anthropological, epistemological and communication/educational social dimensions; and, then, in open and distance education programs. The dominant hegemonic logic is linked to the privileges of artefacts, which are not always the most suitable and/or transparent, within the late capitalism system which legitimizes only one sector of a socio-political-economic structure, with power, although it is said that ICT for open learning is more equitable. Many contradictions hold the illusion of a horizontal pluralism, currently more so with Massive Open Online Courses.