College and career readiness for all students includes supporting the needs of students with disabilities. Ensuring students with disabilities are college and career ready goes beyond academics and must include self-determination skill development. As schools adapt to the implementation of the Common Core State Standards (CCSS) and multi-tiered systems of support (MTSS), it is necessary for teachers to identify ways to teach self-determination skill instruction in conjunction with the CCSS, while considering the needs of students in a MTSS. This article provides teachers with step-by-step instructions for implementing two evidence-based strategies for teaching self-determination skills in the general curriculum supporting students in an MTSS.