Introduction: The 3P and DEDEPRO Models predict interactive relationships among "presage," "process," and "product" variables through teaching and learning of self-regulation. The DEDEPRO Model has established different possibilities for interaction between student characteristics of self-regulation and external characteristics of regulatory teaching. The aim of this investigation is empirical validate the model of four interaction types. Method: The sample included 765 undergraduate students from two universities in the south of Spain. Using an ex post-facto design, the date collection was obtained from three validated instruments: Self-regulation scale (SRQ), the Scales for Assessment of the Teaching-Learning Process (ATLP-S) and the Academic Behaviour Confidence (ABC) scales at two different points in time. Academic performance was evaluated through the final grade for each subject area. Multivariate Analyses were used and from Structural Equation Modelling was used to explore possible causal relationships. Results: Results offer evidence for a consistent, four-fold interaction typology and empirical causal model, thus giving significant confirmation of the proposed rational model. As predicted, the most significant of these interactions was the student's self-regulation with regulatory instruction. Conclusion: The best type of interaction is high personal self-regulation with a highly regulated teaching-learning process, yielding high performance and academic confidence.