This mixed methods case study examined the implementation of a 1:1 iPad initiative in a suburban, co-educational, independent, preK-4th grade elementary school in the United States. This article focuses on how teachers used iPads to differentiate instruction and across multiple content areas. Findings show the processes by which teachers employed iPads demonstrated a myriad of teaching and learning opportunities. Overall, teachers integrated iPads into the existing curriculum to complement or enhance their lessons, provide different choices for students to engage with content, or for them to delve deeper into the content. Additionally, iPads were often used in interdisciplinary ways, involving a combination of at least two different content areas during one lesson.