After the demise of apartheid in South Africa in 1994, 11 languages (English, Afrikaans and 9 indigenous African languages) were given official status. In the higher education landscape, English remains the dominant language of scholarship. At the University of KwaZulu-Natal, English is the main medium of instruction but the institution's language policy provides for the use of isiZulu (one of the indigenous African languages) as an additional medium of instruction. The paper discusses how three of the four colleges of the University are employing isiZulu in this role. This use of isiZulu is analysed through the following four theoretical perspectives: African scholarship, Africanization of higher education, the African Renaissance, and transformation. Whilst there are obviously some challenges in using isiZulu as a medium of instruction, it is very clear that the project deflates the myth that indigenous African languages can only serve in lower levels of education (such as primary schools) and not higher education. The paper is of relevance not only to South African universities, but also to other African (and even non-African) universities that plan to use indigenous languages as media of instruction.