This paper discusses the characteristics of college students with Autism Spectrum Disorder (ASD), examines the results of a survey of college faculty with regard to their understanding and expectations of students with disabilities (including those on the spectrum), and presents suggested guidelines for facilitating access to the curriculum for all learners, including students with ASD. The article explores challenges faced by professors due to the increasing number of students with ASD entering college. Survey results provide a framework for discussion, followed by recommendations for enhancing student success for college students with ASD.