Technological pedagogical content knowledge ("TPACK") is a theoretical framework used primarily in the field of education to facilitate the integration of technology into educational endeavors. This framework can be particularly valuable to librarians, who are heavy users of technology, and can provide a structure that can help librarians to critically examine technologies being considered for integration. In this article, the authors provide an overview of TPACK, discuss its history and uses in libraries and in education, and provide concrete examples illustrating how this framework can be applied to decision-making within libraries.