The Centers for Disease Control and Prevention (CDC) recommends the HPV vaccination for boys and girls starting at age 11, yet adoption rates are low. We use eight focus groups to explore the decision making process, experiences, and social influences, including media and sex education classes, shaping attitudes of male and female college students. We find many students who have misinformation or no knowledge of the vaccination yet are eager to learn more. Due to youths' range of knowledge about the vaccination and varied preparedness for making their own medical decisions, practitioners are in a challenging position to inform and encourage responsible decision making without appearing coercive.